• HOME
  • AWARDS
  • Search
  • Help
Current time: 30-07-2018, 02:18 AM
Hello There, Guest! ( Login — Register )
› TIME PASS ZONE › NEWS & KNOWLEDGE v
1 2 3 4 5 6 ..... 25 Next »

Tech News Discovery of ovarian cancer target paves way for new treatment

Verify your Membership Click Here

Thread Modes
Tech News Discovery of ovarian cancer target paves way for new treatment
urpussysucker Offline
Princess Bee
*******
Supporter of en.roksbi.ruMost Number of Threads
Joined: 05 Aug 2014
Reputation: 4,383


Posts: 81,012
Threads: 4,890

Likes Got: 18,876
Likes Given: 18,676


db Rs: Rs 2,328
#1
12-07-2016, 04:22 PM
Discovery of ovarian cancer target paves way for new treatment
Washington D.C, Jul 11 (ANI): A team of researchers has brought fresh hope in the form of a new treatment target for ovarian cancer aka "the silent killer."

Researchers at Cold Spring Harbor Laboratory arrived at "new insights into signalling events that underlie metastasis in ovarian cancer cells," said researcher Gaofeng Fan.

"The statistics point to the urgent need to address advanced disease - metastasis - in ovarian cancer," Fan noted, adding "The problem is especially difficult because of a feature specific to this form of cancer: ovarian cells move around readily within the peritoneal cavity, via the peritoneal fluid, both under normal conditions, and also, unfortunately, when cancer is present. Thus, in addition to being able to colonize other sites in the body via blood vessels, ovarian cancer cells have another way of migrating. It's very hard to render patients free of the disease via surgery due to this diffusion feature."

The team found a previously undiscovered pathway, through which ovarian cells can be transformed into cancer cells, one they think provides an excellent opportunity for targeting by new drugs, which, when combined with others now in development, may be able to stave off metastatic disease.

The newly uncovered pathway depends on activity of a protein called FER, a member of a family of proteins (called non-receptor tyrosine kinases) that add phosphate groups to other proteins. FER can be found floating in the cytoplasm of cells, and in a series of initial experiments, Fan and the team demonstrated that it is both "upregulated," i.e., overproduced, in ovarian cancer cells, and, importantly, responsible for the elevated motility and invasiveness of such cells. This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

The key discovery made by the team is that FER is able to activate a receptor on the surface of ovarian cells "from below," as it were - by interacting with a portion of the receptor that penetrates the cell membrane and plunges into the cytoplasm. That receptor is a well known target in ovarian cancer. Called MET, it is typically activated when a growth factor called HGF binds it at the cell surface. MET is overexpressed in up to 60% of ovarian tumors and its activation has been implicated in both cancer initiation and in advanced cancers with poor prognosis.

"We showed FER was essential for ovarian cancer cell motility and invasiveness, both in vitro and in vivo," Researcher Nicholas K. Tonks said.

He added, "Considering that frequent amplification of MET accounts for resistance to therapies now in development and to poor prognosis, not only in ovarian cancer but in other cancers too, our findings pinpoint an important new signaling hub, involving the role of FER in MET activation. This may provide a novel strategy for therapeutic intervention, perhaps a drug to suppress FER being administered along with a MET inhibitor."

The study appears in the journal Genes and Development. (ANI)
Find
Reply


« Next Oldest | Next Newest »


Possibly Related Threads...
Thread Author Replies Views Last Post
News & GK  The Salary Of Bahubali 2 Actors Will Shock You In A Big Way honey boy 1 967 03-05-2017, 01:11 PM
Last Post: honey boy
News & GK  Contraceptive pills driving fall in ovarian cancer deaths urpussysucker 0 1,267 07-09-2016, 01:16 PM
Last Post: urpussysucker
News & GK  General signs and symptoms of cancer Joyboy32 1 1,739 11-04-2016, 10:17 AM
Last Post: cnak147
News & GK  How alcohol ups breast cancer risk urpussysucker 2 3,639 17-03-2016, 06:42 PM
Last Post: urpussysucker
Tech News  Blood test may indicate skin cancer relapse urpussysucker 0 1,288 07-03-2016, 04:13 PM
Last Post: urpussysucker
News & GK  ‘Homeopathy is not limited to treatment of cough and cold, can cure cancer as well’ urpussysucker 0 1,349 07-03-2016, 11:54 AM
Last Post: urpussysucker
Tech News  Scientists develop new way to turn sunlight into hydrogen Joyboy32 1 2,218 26-02-2016, 08:19 PM
Last Post: urpussysucker
Tech News  Bengaluru Doctor Invents a Rs. 50 Device To Give Throat Cancer Patients Their Voice A urpussysucker 0 1,594 05-01-2016, 07:39 PM
Last Post: urpussysucker
Tech News  Scientists put final pieces into place for seeing cancer with protons urpussysucker 4 4,909 10-12-2015, 09:05 PM
Last Post: urpussysucker
News & GK  Eat peanuts to protect from cancer & heart disease urpussysucker 2 4,038 03-11-2015, 09:18 PM
Last Post: urpussysucker

  • View a Printable Version
  • Subscribe to this thread


Best Indian Adult Forum XXX Desi Nude Pics Desi Hot Glamour Pics

  • Contact Us
  • en.roksbi.ru
  • Return to Top
  • Mobile Version
  • RSS Syndication
Current time: 30-07-2018, 02:18 AM Powered By © 2012-2018
Linear Mode
Threaded Mode


tamil amma sex story in tamil  telugu masala sex stories  sexmalyalamonly  desi lun  tamel aunty  telugu chat stories  bhabhi jaan  desi suhagraat  indian aunty armpit  apni sex kahani  sexy images of desi aunty  mom son incest toon  sexi stori in urdu  choot ka ras  ma ki sex story  heroines nude  marathisexstories  mastram ki mast kahani in hindi  boor chod  hindi sax stories.com  aunty sex exbii  anjali exbii  marathi aunties photos  sis bro sex kahani  www.desibaba  world best pronstar  sexy seema  women undressing pics  kannad sex story  desi bathing in river  telugu sex stories kathalu  wife gangbang sex story  malayalam sex kambi stories  ww.desi girl.com  desiporn videos  raped by a shemale porn  xxnxx sex stories  girls strip series with face images (sexy girl 200  lesbian vixens  hot anjali mehta  bhabhi ki sex story  Biday balar opohar  sexy blackmail stories  kaam vasna  khuli bur  girltit  sexy malayalam kathakal  sex stories breastfeeding  sexy kahani in urdu fonts  exbii actress  incent sex story  www.mastifuck.com  tmil xxx  indian aunties belly  girls undressing pic  telugu stories with pictures  sexi potos  sophie dee anal creampie  sexy mms leaked  desi hindi kahani  sexy boudi pics  dressed undressed couples  saree navel aunties  10 பேருடன் ஓத்த கதை  pyasi maa  nude indian girlfriends  andhra aunty sex kathalu  मेरी चुत मे  bhai ke sath  kannada sec  mms clips indian  bangla boudi picture  sexy urdu story in urdu  indian sexy in saree  new hindi sexy stori  sexsi hindi kahaniya  lund ka chaska  indiansex storie